Ontology highlight
ABSTRACT:
SUBMITTER: Zouhir S
PROVIDER: S-EPMC5764988 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Zouhir Samira S Robert-Genthon Mylène M Trindade Daniel Maragno DM Job Viviana V Nedeljković Marko M Breyton Cécile C Ebel Christine C Attrée Ina I Dessen Andréa A
Scientific reports 20180111 1
Alpha-2-macroglobulins (A2Ms) are large spectrum protease inhibitors that are major components of the eukaryotic immune system. Pathogenic and colonizing bacteria, such as the opportunistic pathogen Pseudomonas aeruginosa, also carry structural homologs of eukaryotic A2Ms. Two types of bacterial A2Ms have been identified: Type I, much like the eukaryotic form, displays a conserved thioester that is essential for protease targeting, and Type II, which lacks the thioester and to date has been poor ...[more]