Ontology highlight
ABSTRACT:
SUBMITTER: Donnelly C
PROVIDER: S-EPMC5765004 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Donnelly Conor C Dykstra Brad B Mondal Nandini N Huang Junning J Kaskow Belinda J BJ Griffin Russell R Sackstein Robert R Baecher-Allan Clare C
Scientific reports 20180111 1
While human Tregs hold immense promise for immunotherapy, their biologic variability poses challenges for clinical use. Here, we examined clinically-relevant activities of defined subsets of freshly-isolated and culture-expanded human PBMC-derived Tregs. Unlike highly suppressive but plastic memory Tregs (memTreg), naïve Tregs (nvTreg) exhibited the greatest proliferation, suppressive capacity after stimulation, and Treg lineage fidelity. Yet, unlike memTregs, nvTregs lack Fucosyltransferase VII ...[more]