Ontology highlight
ABSTRACT:
SUBMITTER: Balasubramanian P
PROVIDER: S-EPMC5765017 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Balasubramanian Preetha P Williams Constance C Shapiro Mariya B MB Sinangil Faruk F Higgins Keith K Nádas Arthur A Totrov Maxim M Kong Xiang-Peng XP Fiore-Gartland Andrew J AJ Haigwood Nancy L NL Zolla-Pazner Susan S Hioe Catarina E CE
Scientific reports 20180111 1
Immunization with HIV AIDSVAX gp120 vaccines in the phase III VAX003 and VAX004 trials did not confer protection. To understand the shortcomings in antibody (Ab) responses induced by these vaccines, we evaluated the kinetics of Ab responses to the V1V2 and V3 regions of gp120 and the induction of Ab-mediated antiviral functions during the course of 7 vaccinations over a 30.5-month period. Plasma samples from VAX003 and VAX004 vaccinees and placebo recipients were measured for ELISA-binding Abs a ...[more]