Ontology highlight
ABSTRACT:
SUBMITTER: Stoiber K
PROVIDER: S-EPMC5765225 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Stoiber Katharina K Nagło Olga O Pernpeintner Carla C Zhang Siwei S Koeberle Andreas A Ulrich Melanie M Werz Oliver O Müller Rolf R Zahler Stefan S Lohmüller Theobald T Feldmann Jochen J Braig Simone S
British journal of cancer 20171107 1
<h4>Background</h4>Although altered membrane physiology has been discussed within the context of cancer, targeting membrane characteristics by drugs being an attractive therapeutic strategy has received little attention so far.<h4>Methods</h4>Various acetyl-CoA carboxylase 1 (ACC1), and fatty acid synthase (FASN) inhibitors (like Soraphen A and Cerulenin) as well as genetic knockdown approaches were employed to study the effects of disturbed phospholipid composition on membrane properties and it ...[more]