Ontology highlight
ABSTRACT:
SUBMITTER: Nishitsuji H
PROVIDER: S-EPMC5765299 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nishitsuji Hironori H Harada Keisuke K Ujino Saneyuki S Zhang Jing J Kohara Michinori M Sugiyama Masaya M Mizokami Masashi M Shimotohno Kunitada K
Cancer science 20171207 1
Chronic infection with hepatitis B virus (HBV) increases the risk of developing fibrosis, cirrhosis or hepatocellular carcinoma. Current therapies are limited to type-I interferons and/or nucleos(t)ide analogues; however, these are only partially effective. The development of novel anti-HBV agents for new treatment strategies has been hampered by the lack of a suitable system that allows the in vitro replication of HBV. Studies of virus infection/replication at the molecular level using wild-typ ...[more]