The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease.

ABSTRACT: BACKGROUND:Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for death and serious infection in PM/DM-ILD using the multicenter database. METHODS:We retrospectively reviewed baseline demographic, clinical and laboratory findings, treatment regimens and outcomes in patients with PM/DM-ILD. The distribution of ILD lesions was evaluated in four divided lung zones of high-resolution computed tomography images. RESULTS:Of 116 patients with PM/DM-ILD, 14 died within 6 months from the diagnosis. As independent risk factors for early death, extended ILD lesions in upper lung fields (odds ratio (OR) 8.01, p?=?0.016) and hypocapnia (OR 6.85, p?=?0.038) were identified. Serious infection was found in 38 patients, including 11 patients who died of respiratory or multiple infections. The independent risk factors were high serum KL-6 (OR 3.68, p?=?0.027), high initial dose of prednisolone (PSL) (OR 4.18, p?=?0.013), and combination immunosuppressive therapies (OR 5.51, p?

SUBMITTER: Sugiyama Y 

PROVIDER: S-EPMC5765702 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature