Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC5766205 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Liu Dekang D Frederiksen Jane H JH Liberti Sascha E SE Lützen Anne A Keijzers Guido G Pena-Diaz Javier J Rasmussen Lene Juel LJ
Nucleic acids research 20170901 16
DNA mismatch repair (MMR) is a highly-conserved DNA repair mechanism, whose primary role is to remove DNA replication errors preventing them from manifesting as mutations, thereby increasing the overall genome stability. Defects in MMR are associated with increased cancer risk in humans and other organisms. Here, we characterize the interaction between MMR and a proofreading-deficient allele of the human replicative DNA polymerase delta, PolδD316A;E318A, which has a higher capacity for strand di ...[more]