Cellular Decision Making by Non-Integrative Processing of TLR Inputs.
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ABSTRACT:
SUBMITTER: Kellogg RA
PROVIDER: S-EPMC5766323 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Cellular Decision Making by Non-Integrative Processing of TLR Inputs.
Kellogg Ryan A RA Tian Chengzhe C Etzrodt Martin M Tay Savaş S
Cell reports 20170401 1
Cells receive a multitude of signals from the environment, but how they process simultaneous signaling inputs is not well understood. Response to infection, for example, involves parallel activation of multiple Toll-like receptors (TLRs) that converge on the nuclear factor κB (NF-κB) pathway. Although we increasingly understand inflammatory responses for isolated signals, it is not clear how cells process multiple signals that co-occur in physiological settings. We therefore examined a bacterial ...[more]
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