Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi TS
PROVIDER: S-EPMC5766498 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Takahashi Tomio S TS Hirade Yoshihiro Y Toma Aya A Sato Yusuke Y Yamagata Atsushi A Goto-Ito Sakurako S Tomita Akiko A Nakada Shinichiro S Fukai Shuya S
Nature communications 20180112 1
The E3 ubiquitin (Ub) ligase RNF168 plays a critical role in the initiation of the DNA damage response to double-strand breaks (DSBs). The recruitment of RNF168 by ubiquitylated targets involves two distinct regions, Ub-dependent DSB recruitment module (UDM) 1 and UDM2. Here we report the crystal structures of the complex between UDM1 and Lys63-linked diUb (K63-Ub<sub>2</sub>) and that between the C-terminally truncated UDM2 (UDM2ΔC) and K63-Ub<sub>2</sub>. In both structures, UDM1 and UDM2ΔC fo ...[more]