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The RacGAP ?-Chimaerin is essential for cerebellar granule cell migration.

ABSTRACT: During mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of the External Granule Layer (EGL). Postmitotic granule progenitors migrate tangentially in the inner EGL before switching to migrate radially inward, past the Purkinje cell layer, to achieve their final position in the mature Granule Cell Layer (GCL). Here, we show that the RacGAP ?-chimaerin is expressed by a small population of late-born, premigratory granule cells. ?-chimaerin deficiency causes a subset of granule cells to become arrested in the EGL, where they differentiate and form ectopic neuronal clusters. These clusters of granule cells are able to recruit aberrantly projecting mossy fibers. Collectively, these data suggest a role for ?-chimaerin as an intracellular mediator of Cerebellar Granule Cell radial migration.

SUBMITTER: Estep JA

PROVIDER: S-EPMC5766509 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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The RacGAP β-Chimaerin is essential for cerebellar granule cell migration.

Estep Jason A JA Wong Wenny W Wong Yiu-Cheung E YE Loui Brian M BM Riccomagno Martin M MM

Scientific reports 20180112 1

During mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of the External Granule Layer (EGL). Postmitotic granule progenitors migrate tangentially in the inner EGL before switching to migrate radially inward, past the Purkinje cell layer, to achieve their final position in the mature Granule Cell Layer (GCL). Here, we show that the RacGAP β-chimaerin is expressed by a small population of late-born, premigratory granule cells. β-chimaerin deficienc ...[more]

PMID: 29330522

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