Dataset Information

The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.

ABSTRACT: The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to eliminate heterogeneity within the sample by only recruiting affective disorder patients and find associations between COMT polymorphisms and defined suicidal phenotypes. In a sample of 258 affective disorder patients a detailed clinical assessment (e.g. CTQ, SCAN, HAMD, SBQ-R, VI-SURIAS, LPC) was performed. DNA of peripheral blood samples was genotyped using TaqMan® SNP Genotyping Assays. We observed that the haplotype GAT of rs737865, rs6269, rs4633 is significantly associated with suicide attempt (p?=?0.003 [pcorr?=?0.021]), and that there is a tendency towards self-harming behaviour (p?=?0.02 [pcorr?=?0.08]) and also NSSI (p?=?0.03 [pcorr?=?0.08]), though the p values did not resist multiple testing correction. The same effect we observed with the 4-marker slide window haplotype, GATA of rs737865, rs6269, rs4633, rs4680 (p?=?0.009 [pcorr?=?0.045]). The findings support an association between the COMT gene and suicidal behaviour phenotypes with and without childhood maltreatment as environmental factor.

SUBMITTER: Bernegger A

PROVIDER: S-EPMC5766555 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.

Bernegger Alexandra A Kienesberger Klemens K Carlberg Laura L Swoboda Patrick P Ludwig Birgit B Koller Romina R Inaner Michelle M Zotter Melanie M Kapusta Nestor N Aigner Martin M Haslacher Helmuth H Kasper Siegfried S Schosser Alexandra A

Scientific reports 20180112 1

The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to eliminate heterogeneity within the sample by only recruiting affective disorder patients and find associations between COMT polymorphisms and defined suicidal phenotypes. In a sample ...[more]

PMID: 29330410

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Project description:BACKGROUND:Non-suicidal self-injury is being increasingly recognised as a prominent public health concern. Identification of early and modifiable risk factors is necessary to advance the screening and intervention efforts, particularly early detection of at-risk individuals. We aimed to examine childhood maltreatment, including its specific subtypes, in relation to non-suicidal self-injury. METHODS:We did a comprehensive meta-analysis of childhood maltreatment (overall, sexual abuse, physical abuse and neglect, and emotional abuse and neglect) in association with non-suicidal self-injury. We also provided a qualitative review of mediators and moderators of this association. We identified relevant articles published from inception to Sept 25, 2017, through a systematic search of Embase, MEDLINE, and PsycINFO. We extracted continuous and categorical data and assessed for potential moderators using ten study characteristics. We generated random-effects models for analysis and evaluated for publication bias. FINDINGS:We identified 71 publications that met eligibility criteria. Overall childhood maltreatment was associated with non-suicidal self-injury (odds ratio 3·42, 95% CI 2·74-4·26), and effect sizes for maltreatment subtypes ranged from 1·84 (1·45-2·34) for childhood emotional neglect to 3·03 (2·56-3·54) for childhood emotional abuse. Publication bias was not evident, except in the case of childhood emotional neglect. Across multiple maltreatment subtypes, we found stronger associations with non-suicidal self-injury in non-clinical samples. INTERPRETATION:With the exception of childhood emotional neglect, childhood maltreatment and its subtypes are associated with non-suicidal self-injury. Screening of childhood maltreatment history in non-suicidal self-injury risk assessments might hold particular value in community settings, and increased attention to childhood emotional abuse is warranted. FUNDING:National Institute of Mental Health.

Dataset Information

The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.

Publications

The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.

Similar Datasets

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