Ontology highlight
ABSTRACT:
SUBMITTER: Resch TK
PROVIDER: S-EPMC5766576 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20180112 1
To improve the safety and efficacy of oral rotavirus vaccines, we developed an inactivated rotavirus vaccine (IRV) for parenteral administration. Since it remains unknown whether parenteral vaccination can induce mucosal immunity, we performed a comprehensive assessment of immune responses to IRV in mice with an adjuvant-free dissolving polymer MN patch or by alum-adjuvanted IM injection. We demonstrated that IRV induced the expression of the gut homing receptor LPAM-1 on T and B cells in spleen ...[more]