Ontology highlight
ABSTRACT:
SUBMITTER: van IJzendoorn DGP
PROVIDER: S-EPMC5766951 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
van IJzendoorn David G P DGP Forghany Zary Z Liebelt Frauke F Vertegaal Alfred C AC Jochemsen Aart G AG Bovée Judith V M G JVMG Szuhai Karoly K Baker David A DA
The Journal of biological chemistry 20171117 52
Epithelioid hemangioma is a locally aggressive vascular neoplasm, found in bones and soft tissue, whose cause is currently unknown, but may involve oncogene activation. FOS is one of the earliest viral oncogenes to be characterized, and normal cellular FOS forms part of the activator protein 1 (AP-1) transcription factor complex, which plays a pivotal role in cell growth, differentiation, and survival as well as the DNA damage response. Despite this, a causal link between aberrant FOS function a ...[more]