Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.
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ABSTRACT:
SUBMITTER: Stieglitz MS
PROVIDER: S-EPMC5767300 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.
Stieglitz Marc S MS Fenske Stefanie S Hammelmann Verena V Becirovic Elvir E Schöttle Verena V Delorme James E JE Schöll-Weidinger Martha M Mader Robert R Deussing Jan J Wolfer David P DP Seeliger Mathias W MW Albrecht Urs U Wotjak Carsten T CT Biel Martin M Michalakis Stylianos S Wahl-Schott Christian C
Frontiers in molecular neuroscience 20180109
Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) in the nervous system are implicated in a variety of neuronal functions including learning and memory, regulation of vigilance states and pain. Dysfunctions or genetic loss of these channels have been shown to cause human diseases such as epilepsy, depression, schizophrenia, and Parkinson's disease. The physiological functions of HCN1 and HCN2 channels in the nervous system have been analyzed using genetic knockout mouse models. ...[more]
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