Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.
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ABSTRACT:
SUBMITTER: Dupere-Richer D
PROVIDER: S-EPMC5767522 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.
Dupéré-Richer Daphné D Licht Jonathan D JD
Current opinion in hematology 20170701 4
<h4>Purpose of review</h4>Next generation sequencing and large-scale analysis of patient specimens has created a more complete picture of multiple myeloma (MM) revealing that epigenetic deregulation is a prominent factor in MM pathogenesis.<h4>Recent findings</h4>Over half of MM patients have mutations in genes encoding epigenetic modifier enzymes. The DNA methylation profile of MM is related to the stage of the disease and certain classes of mutations in epigenetic modifiers are more prevalent ...[more]
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