Ontology highlight
ABSTRACT:
SUBMITTER: Guo Q
PROVIDER: S-EPMC5767861 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Guo Qiong Q Liao Shanhui S Zhu Zhongliang Z Li Yue Y Li Fudong F Xu Chao C
The Journal of biological chemistry 20171128 2
A well-controlled microtubule organization is essential for intracellular transport, cytoskeleton maintenance, and cell development. KN motif and ankyrin repeat domain-containing protein 1 (KANK1), a member of KANK family, recruits kinesin family member 21A (KIF21A) to the cell cortex to control microtubule growth via its C-terminal ankyrin domain. However, how the KANK1 ankyrin domain recognizes KIF21A and whether other KANK proteins can also bind KIF21A remain unknown. Here, using a combinatio ...[more]