Ontology highlight
ABSTRACT:
SUBMITTER: Spyrakis F
PROVIDER: S-EPMC5767890 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Spyrakis Francesca F Celenza Giuseppe G Marcoccia Francesca F Santucci Matteo M Cross Simon S Bellio Pierangelo P Cendron Laura L Perilli Mariagrazia M Tondi Donatella D
ACS medicinal chemistry letters 20171126 1
Bacterial resistance has become a worldwide concern after the emergence of metallo-β-lactamases (MBLs). They represent one of the major mechanisms of bacterial resistance against beta-lactam antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 NDM-1, the most prevalent type, is extremely efficient in inactivating nearly all-available antibiotics including last resort carbapenems. No inhibitors for NDM-1 are currently available in therapy, making the spread of NDM-1 producing bacterial strain ...[more]