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Computer aided epitope design as a peptide vaccine component against Lassa virus.

ABSTRACT: Lassa virus (LASV) is an arena virus causing hemorrhagic fever and it is endemic in several regions of West Africa. The disease-causing virus records high mortality rate in endemic regions due to lack of appropriate treatment and prevention strategies. Therefore, it is of interest to design and develop viable vaccine components against the virus. We used the Lassa virus envelope glyco-proteins as a vaccine target to identify linear peptides as potential epitopes with immunogenic properties by computer aided epitope prediction tools. We report a T-cell epitope 'LLGTFTWTL' and a B-cell epitope 'AELKCFGNTAVAKCNE' with predicted potential immunogenicity for further in vivo and in vitro consideration.

SUBMITTER: Faisal AM

PROVIDER: S-EPMC5767920 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Computer aided epitope design as a peptide vaccine component against Lassa virus.

Faisal Ar-Rafi Md AM Imtiaz Syed Hassan SH Zerin Tasnim T Rahman Tania T Shekhar Hossain Uddin HU

Bioinformation 20171231 12

Lassa virus (LASV) is an arena virus causing hemorrhagic fever and it is endemic in several regions of West Africa. The disease-causing virus records high mortality rate in endemic regions due to lack of appropriate treatment and prevention strategies. Therefore, it is of interest to design and develop viable vaccine components against the virus. We used the Lassa virus envelope glyco-proteins as a vaccine target to identify linear peptides as potential epitopes with immunogenic properties by co ...[more]

PMID: 29379262

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