Associations between inflammatory markers and cognitive function in breast cancer patients receiving chemotherapy.

ABSTRACT:

Background

Cancer-related cognitive impairment (CRCI) is often related to chemotherapy. Increased chronic inflammation is believed to play a key role in the development of CRCI related to chemotherapy but studies assessing this hypothesis specifically in patients receiving chemotherapy are rare.

Methods

We assessed several cognitive domains using the Cambridge Neuropsychological Test Automated Battery (CANTAB) in twenty-two breast cancer patients currently receiving chemotherapy. We also measured inflammatory cytokine and receptor (MCP-1, TNF-α, sTNFRI, sTNFRII) concentrations in patient sera using Luminex assays. These concentrations were log-transformed to obtain a normal distribution. Associations between log-transformed cytokines and cognition were evaluated using Pearso

SUBMITTER: Williams AM 

PROVIDER: S-EPMC5768199 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature