Ontology highlight
ABSTRACT:
SUBMITTER: Gu Z
PROVIDER: S-EPMC5768407 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Gu Zhichao Z Zhang Huafeng H Li Yong Y Shen Susu S Yin Xiaonan X Zhang Wei W Cheng Ruimin R Zhang Yong Y Zhang Xiaoyan X Chen Hui H Huang Bo B Cao Yuchun Y
Oncotarget 20171207 69
Metabolic reprogramming allows tumor cells to thrive in the typically hypoxic tumor microenvironment. Using immunodetection and clinical data analyses, we demonstrate here that fumarylacetoacetate hydrolase (FAH) is highly expressed in melanoma and correlates with poor survival. FAH knockdown inhibits proliferation and migration, while promoting apoptosis in melanoma cells, result in prolonged survival in tumor-bearing mice. Molecular analyses using real time RT-PCR, western blot, and <sup>13</s ...[more]