Unknown

Dataset Information

0

Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model.

ABSTRACT: Gut-derived short-chain fatty acids (SCFA), formed by microbial fermentation of dietary fibers, are believed to be involved in the etiology of obesity and diabetes. Previous data from our group showed that colonic infusions of physiologically relevant SCFA mixtures attenuated whole-body lipolysis in overweight men. To further study potential mechanisms involved in the antilipolytic properties of SCFA, we aimed to investigate the in vitro effects of SCFA incubations on intracellular lipolysis and signaling using a human white adipocyte model, the human multipotent adipose tissue-derived stem (hMADS) cells.hMADS adipocytes were incubated with mixtures of acetate, propionate, and butyrate or single SCFA (acetate, propionate and butyrate) in concentrations ranging between 1?µmol/L and 1?mmol/L. Glycerol release and lipase activation was investigated during basal conditions and following ?-adrenergic stimulation.SCFA mixtures high in acetate and propionate decreased basal glycerol release, when compared to control (P?

SUBMITTER: Jocken JWE 

PROVIDER: S-EPMC5768634 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model.

Jocken Johan W E JWE   González Hernández Manuel A MA   Hoebers Nicole T H NTH   van der Beek Christina M CM   Essers Yvonne P G YPG   Blaak Ellen E EE   Canfora Emanuel E EE  

Frontiers in endocrinology 20180111

<h4>Background and aims</h4>Gut-derived short-chain fatty acids (SCFA), formed by microbial fermentation of dietary fibers, are believed to be involved in the etiology of obesity and diabetes. Previous data from our group showed that colonic infusions of physiologically relevant SCFA mixtures attenuated whole-body lipolysis in overweight men. To further study potential mechanisms involved in the antilipolytic properties of SCFA, we aimed to investigate the <i>in vitro</i> effects of SCFA incubat  ...[more]

Similar Datasets

Transcriptomics Short chain fatty acids induce ANGPTL4 via PPARγ
2013-03-11 | GSE43065 | GEO
Transcriptomics T Cell Genes Regulated by Short Chain Fatty Acids
2018-06-13 | GSE31585 | GEO
Unknown The Divergent Immunomodulatory Effects of Short Chain Fatty Acids and Medium Chain Fatty Acids.
| S-EPMC8234078 | biostudies-literature
Unknown Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids.
| S-EPMC6971417 | biostudies-literature
Unknown Short-chain fatty acids activate acetyltransferase p300
| S-EPMC8585482 | biostudies-literature
Transcriptomics SHORT CHAIN FATTY ACIDS MITIGATE OSTEOCLAST-MEDIATED ARTHRITIC BONE REMODELLING
2024-01-01 | GSE241033 | GEO
Transcriptomics Transcriptomic analysis for response of EHEC to short chain fatty acids
2010-05-17 | E-GEOD-12903 | biostudies-arrayexpress
Transcriptomics Short-chain fatty acids improve post-stroke recovery via immunological mechanisms.
2020-01-01 | GSE131788 | GEO
Transcriptomics Transcriptomic analysis for response of EHEC to short chain fatty acids
2008-11-01 | GSE12903 | GEO
Unknown Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans.
| S-EPMC6715624 | biostudies-literature