Ontology highlight
ABSTRACT:
SUBMITTER: Shiraishi Y
PROVIDER: S-EPMC5768704 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Shiraishi Yutaro Y Natsume Mei M Kofuku Yutaka Y Imai Shunsuke S Nakata Kunio K Mizukoshi Toshimi T Ueda Takumi T Iwaï Hideo H Shimada Ichio I
Nature communications 20180115 1
The C-terminal region of G-protein-coupled receptors (GPCRs), stimulated by agonist binding, is phosphorylated by GPCR kinases, and the phosphorylated GPCRs bind to arrestin, leading to the cellular responses. To understand the mechanism underlying the formation of the phosphorylated GPCR-arrestin complex, we performed NMR analyses of the phosphorylated β<sub>2</sub>-adrenoceptor (β<sub>2</sub>AR) and the phosphorylated β<sub>2</sub>AR-β-arrestin 1 complex, in the lipid bilayers of nanodisc. Her ...[more]