Ontology highlight
ABSTRACT:
SUBMITTER: Stevenson NL
PROVIDER: S-EPMC5769581 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Journal of cell science 20171101 24
The Golgi is the cellular hub for complex glycosylation, controlling accurate processing of complex proteoglycans, receptors, ligands and glycolipids. Its structure and organisation are dependent on golgins, which tether cisternal membranes and incoming transport vesicles. Here, we show that knockout of the largest golgin, giantin, leads to substantial changes in gene expression but only limited effects on Golgi structure. Notably, 22 Golgi-resident glycosyltransferases, but not glycan-processin ...[more]