Relations between cortical thickness, serotonin 1A receptor binding, and structural connectivity: A multimodal imaging study.

ABSTRACT: Serotonin 1A (5-HT_1A ) receptors play a direct role in neuronal development, cell proliferation, and dendritic branching. We hypothesized that variability in 5-HT_1A binding can affect cortical thickness, and may account for a subtype of major depressive disorder (MDD) in which both are altered. To evaluate this, we measured cortical thickness from structural magnetic resonance imaging (MRI) and 5-HT_1A binding by positron emission tomography (PET) in an exploratory study. To examine a range of 5-HT_1A binding and cortical thickness values, we recruited 25 healthy controls and 19 patients with MDD. We hypothesized increased 5-HT_1A binding in the raphe nucleus (RN) would be negatively associated with cortical thickness due to reduced serot

SUBMITTER: Pillai RLI 

PROVIDER: S-EPMC5769701 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature