Ontology highlight
ABSTRACT:
SUBMITTER: Bassat E
PROVIDER: S-EPMC5769930 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Bassat Elad E Mutlak Yara Eid YE Genzelinakh Alex A Shadrin Ilya Y IY Baruch Umansky Kfir K Yifa Oren O Kain David D Rajchman Dana D Leach John J Riabov Bassat Daria D Udi Yael Y Sarig Rachel R Sagi Irit I Martin James F JF Bursac Nenad N Cohen Shenhav S Tzahor Eldad E
Nature 20170605 7662
The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of life. Here we show that changes in the composition of the extracellular matrix during this week can affect cardiomyocyte growth and differentiation in mice. We identify agrin, a component of neonatal extracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts. In vitro, recombinant agrin prom ...[more]