Dataset Information

Exercise-induced circulating microRNA changes in athletes in various training scenarios.

ABSTRACT: The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT).30 young male athletes of white European origin (mean age: 22.5 ± 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randomly assigned to three possible training scenarios: EXPL, HYP or HITT and participated in 8-week-long program in given arm. Blood plasma samples were collected at the baseline and at week 5 and 8 and anthropometric and physical activity parameters were measured. Pre- and post-intervention characteristics were compared and participants were further evaluated as responders (RES) or non-responders (NRES). RES/NRES status was established for the following characteristics: 300°/s right leg extension (t300), 60°/s right leg extension (t60), isometric extension (IE), vertical jump, isometric extension of the right leg and body fat percentage (BFP).No differences in miRNA levels were apparent between the intervention groups at baseline. No statistically significant prediction role was observed using crude univariate stepwise regression model analysis where RES/NRES status for t300, t60, IE, vertical jump and pFM was used as a dependent variable and miR-21, miR-222, miR-16 and miR-93 levels at baseline were used as independent variables. The baseline levels of miR-93 expressed an independent prediction role for responder status based on isometric extension of the right leg (beta estimate 0.76, 95% CI: -0.01; 1.53, p = 0.052).The results of the study indicate that 8-week-long explosive strength training, hypertrophic strength training and high-intensity interval training regimens are associated with significant changes in miR-16, mir-21, miR-222 and miR-93 levels compared to a baseline in athletic young men.

SUBMITTER: Horak M

PROVIDER: S-EPMC5770042 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Exercise-induced circulating microRNA changes in athletes in various training scenarios.

Horak Martin M Zlamal Filip F Iliev Robert R Kucera Jan J Cacek Jan J Svobodova Lenka L Hlavonova Zuzana Z Kalina Tomas T Slaby Ondrej O Bienertova-Vasku Julie J

PloS one 20180116 1

<h4>Background</h4>The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT).<h4>Methods</h4>30 young male athletes of white European origin (mean age: 22.5 ± 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randoml ...[more]

PMID: 29338015

Similar Datasets

Project description:ContextAnterior cruciate ligament (ACL) injuries are common in female athletes and are related to poor neuromuscular control. Comprehensive neuromuscular training has been shown to improve biomechanics; however, we do not know which component of neuromuscular training is most responsible for the changes.ObjectiveTo assess the efficacy of either a 4-week core stability program or plyometric program in altering lower extremity and trunk biomechanics during a drop vertical jump (DVJ).DesignCohort study.SettingHigh school athletic fields and motion analysis laboratory.Patients or other participantsTwenty-three high school female athletes (age = 14.8 ± 0.8 years, height = 1.7 ± 0.07 m, mass = 57.7 ± 8.5 kg).Intervention(s)Independent variables were group (core stability, plyometric, control) and time (pretest, posttest). Participants performed 5 DVJs at pretest and posttest. Intervention participants engaged in a 4-week core stability or plyometric program.Main outcome measure(s)Dependent variables were 3-dimensional hip, knee, and trunk kinetics and kinematics during the landing phase of a DVJ. We calculated the group means and associated 95% confidence intervals for the first 25% of landing. Cohen d effect sizes with 95% confidence intervals were calculated for all differences.ResultsWe found within-group differences for lower extremity biomechanics for both intervention groups (P ? .05). The plyometric group decreased the knee-flexion and knee internal-rotation angles and the knee-flexion and knee-abduction moments. The core stability group decreased the knee-flexion and knee internal-rotation angles and the hip-flexion and hip internal-rotation moments. The control group decreased the knee external-rotation moment. All kinetic changes had a strong effect size (Cohen d > 0.80).ConclusionsBoth programs resulted in biomechanical changes, suggesting that both types of exercises are warranted for ACL injury prevention and should be implemented by trained professionals.

Dataset Information

Exercise-induced circulating microRNA changes in athletes in various training scenarios.

Publications

Exercise-induced circulating microRNA changes in athletes in various training scenarios.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets