Should Transfusion Trigger Thresholds Differ for Critical Care Versus Perioperative Patients? A Meta-Analysis of Randomized Trials.

ABSTRACT:

Objective

To address the significant uncertainty as to whether transfusion thresholds for critical care versus surgical patients should differ.

Design

Meta-analysis of randomized controlled trials.

Setting

Medline, EMBASE, and Cochrane Library searches were performed up to 15 June 2016.

Patients

Trials had to enroll adult surgical or critically ill patients for inclusion.

Interventions

Studies had to compare a liberal versus restrictive threshold for the transfusion of allogeneic packed RBCs.

Measurements and main results

The primary outcome was 30-day all-cause mortality, sub-grouped by surgical and critical care patients. Secondary outcomes included myocardial infarction, stroke, renal failure, allogeneic blood exposure, and length of stay. Odds

SUBMITTER: Chong MA 

PROVIDER: S-EPMC5770109 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature