Molecular Testing for Oncogenic Gene Alterations in Pediatric Thyroid Lesions.

ABSTRACT: BACKGROUND:Thyroid nodules are less common in pediatric patients (i.e., those ≤18 years) than they are in adults. The Bethesda System for Reporting Thyroid Cytopathology allows for individual risk stratification, but a significant number of nodules are indeterminate. Incorporating gene mutation panels and gene expression classifiers may aid in preoperative diagnosis. The overall aim of this study was to assess the prevalence of oncogene alterations in a representative pediatric population and across a broad-spectrum of thyroid tumor diagnoses. METHODS:This was a retrospective cross-sectional evaluation of 115 archived samples, including: 47 benign (29 follicular adenoma, 11 diffuse hyperplasia, four thyroiditis, and three multinodular goiter), six follicular thyroid carcinomas (FTC), 24 fo

SUBMITTER: Mostoufi-Moab S 

PROVIDER: S-EPMC5770125 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature