Ontology highlight
ABSTRACT:
SUBMITTER: Hogan MJ
PROVIDER: S-EPMC5770335 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Virology 20171122
HIV-1 envelope (Env)-based vaccines have so far largely failed to induce antibodies that prevent HIV-1 infection. One factor proposed to limit the immunogenicity of cell-associated Env is its low level of expression on the cell surface, restricting accessibility to antibodies. Using a vaccinia prime/protein boost protocol in mice, we explored the immunologic effects of mutations in the Env cytoplasmic tail (CT) that increased surface expression, including partial truncation and ablation of a tyr ...[more]