Ontology highlight
ABSTRACT:
SUBMITTER: Bernstock JD
PROVIDER: S-EPMC5770374 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Bernstock Joshua D JD Ye Daniel G DG Griffin Allison A Lee Yang-Ja YJ Lynch John J Latour Lawrence L LL Friedman Gregory K GK Maric Dragan D Hallenbeck John M JM
Frontiers in neurology 20180112
Posttranslational modification by small ubiquitin-like modifier (SUMO) regulates myriad physiological processes within cells and has been demonstrated to be highly activated in murine brains after cerebral ischemia. Numerous <i>in vitro</i> and murine <i>in vivo</i> studies have demonstrated that this increased SUMO conjugation is an endogenous neuroprotective stress response that has potential in being leveraged to develop novel therapies for ischemic stroke. However, SUMO activation has not ye ...[more]