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Cigarette smoking is associated with an altered vaginal tract metabolomic profile.


ABSTRACT: Cigarette smoking has been associated with both the diagnosis of bacterial vaginosis (BV) and a vaginal microbiota lacking protective Lactobacillus spp. As the mechanism linking smoking with vaginal microbiota and BV is unclear, we sought to compare the vaginal metabolomes of smokers and non-smokers (17 smokers/19 non-smokers). Metabolomic profiles were determined by gas and liquid chromatography mass spectrometry in a cross-sectional study. Analysis of the 16S rRNA gene populations revealed samples clustered into three community state types (CSTs) ---- CST-I (L. crispatus-dominated), CST-III (L. iners-dominated) or CST-IV (low-Lactobacillus). We identified 607 metabolites, including 12 that differed significantly (q-value?

SUBMITTER: Nelson TM 

PROVIDER: S-EPMC5770521 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Cigarette smoking is associated with an altered vaginal tract metabolomic profile.

Nelson T M TM   Borgogna J C JC   Michalek R D RD   Roberts D W DW   Rath J M JM   Glover E D ED   Ravel J J   Shardell M D MD   Yeoman C J CJ   Brotman R M RM  

Scientific reports 20180116 1


Cigarette smoking has been associated with both the diagnosis of bacterial vaginosis (BV) and a vaginal microbiota lacking protective Lactobacillus spp. As the mechanism linking smoking with vaginal microbiota and BV is unclear, we sought to compare the vaginal metabolomes of smokers and non-smokers (17 smokers/19 non-smokers). Metabolomic profiles were determined by gas and liquid chromatography mass spectrometry in a cross-sectional study. Analysis of the 16S rRNA gene populations revealed sam  ...[more]

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