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IL-27p28 Production by XCR1+ Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8+ T Cell Responses.


ABSTRACT: It is well accepted that the innate response is a necessary prerequisite to the formation of the adaptive response. This is true for T cell responses against infections or adjuvanted subunit vaccination. However, specific innate parameters with predictive value for the magnitude of an adjuvant-elicited T cell response have yet to be identified. We previously reported how T cell responses induced by subunit vaccination were dependent on the cytokine IL-27. These findings were unexpected, given that T cell responses to an infection typically increase in the absence of IL-27. Using a novel IL-27p28-eGFP reporter mouse, we now show that the degree to which an adjuvant induces IL-27p28 production from dendritic cells and monocytes directly predicts the magnitude of the T cell response elicited. To our knowledge, these data are the first to identify a concrete innate correlate of vaccine-elicited cellular immunity, and they have significant practical and mechanistic implications for subunit vaccine biology.

SUBMITTER: Kilgore AM 

PROVIDER: S-EPMC5771264 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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IL-27p28 Production by XCR1<sup>+</sup> Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8<sup>+</sup> T Cell Responses.

Kilgore Augustus M AM   Welsh Seth S   Cheney Elizabeth E EE   Chitrakar Alisha A   Blain Trevor J TJ   Kedl Benjamin J BJ   Hunter Chris A CA   Pennock Nathan D ND   Kedl Ross M RM  

ImmunoHorizons 20180101 1


It is well accepted that the innate response is a necessary prerequisite to the formation of the adaptive response. This is true for T cell responses against infections or adjuvanted subunit vaccination. However, specific innate parameters with predictive value for the magnitude of an adjuvant-elicited T cell response have yet to be identified. We previously reported how T cell responses induced by subunit vaccination were dependent on the cytokine IL-27. These findings were unexpected, given th  ...[more]

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