Browse
Submit Data
Databases
API
Help

Dataset Information

21 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

NONPARAMETRIC GOODNESS-OF-FIT TESTS FOR UNIFORM STOCHASTIC ORDERING.

ABSTRACT: We propose Lp distance-based goodness-of-fit (GOF) tests for uniform stochastic ordering with two continuous distributions F and G, both of which are unknown. Our tests are motivated by the fact that when F and G are uniformly stochastically ordered, the ordinal dominance curve R = FG-1 is star-shaped. We derive asymptotic distributions and prove that our testing procedure has a unique least favorable configuration of F and G for p ? [1,?]. We use simulation to assess finite-sample performance and demonstrate that a modified, one-sample version of our procedure (e.g., with G known) is more powerful than the one-sample GOF test suggested by Arcones and Samaniego (2000, Annals of Statistics). We also discuss sample size determination. We illustrate our methods using data from a pharmacology study evaluating the effects of administering caffeine to prematurely born infants.

SUBMITTER: Tang CF

PROVIDER: S-EPMC5771311 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

NONPARAMETRIC GOODNESS-OF-FIT TESTS FOR UNIFORM STOCHASTIC ORDERING.

Tang Chuan-Fa CF Wang Dewei D Tebbs Joshua M JM

Annals of statistics 20171215 6

We propose Lp distance-based goodness-of-fit (GOF) tests for uniform stochastic ordering with two continuous distributions F and G, both of which are unknown. Our tests are motivated by the fact that when F and G are uniformly stochastically ordered, the ordinal dominance curve R = FG-1 is star-shaped. We derive asymptotic distributions and prove that our testing procedure has a unique least favorable configuration of F</i ...[more]

PMID: 29353943

Similar Datasets

More powerful goodness-of-fit tests for uniform stochastic ordering.

Project description:The ordinal dominance curve (ODC) is a useful graphical tool to compare two population distributions. These distributions are said to satisfy uniform stochastic ordering (USO) if the ODC for them is star-shaped. A goodness-of-fit test for USO was recently proposed when both distributions are unknown. This test involves calculating the Lp distance between an empirical estimator of the ODC and its least star-shaped majorant. The least favorable configuration of the two distributions was established so that proper critical values could be determined; i.e., to control the probability of type I error for all star-shaped ODCs. However, the use of these critical values can lead to a conservative test and minimal power to detect certain non-star-shaped alternatives. Two new methods for determining data-dependent critical values are proposed. Simulation is used to show both methods can provide substantial increases in power while still controlling the size of the distance-based test. The methods are also applied to a data set involving premature infants. An R package that implements all tests is provided.

| S-EPMC7453724 | biostudies-literature

Goodness-of-Fit Tests and Nonparametric Adaptive Estimation for Spike Train Analysis.

Project description:When dealing with classical spike train analysis, the practitioner often performs goodness-of-fit tests to test whether the observed process is a Poisson process, for instance, or if it obeys another type of probabilistic model (Yana et al. in Biophys. J. 46(3):323-330, 1984; Brown et al. in Neural Comput. 14(2):325-346, 2002; Pouzat and Chaffiol in Technical report, http://arxiv.org/abs/arXiv:0909.2785, 2009). In doing so, there is a fundamental plug-in step, where the parameters of the supposed underlying model are estimated. The aim of this article is to show that plug-in has sometimes very undesirable effects. We propose a new method based on subsampling to deal with those plug-in issues in the case of the Kolmogorov-Smirnov test of uniformity. The method relies on the plug-in of good estimates of the underlying model that have to be consistent with a controlled rate of convergence. Some nonparametric estimates satisfying those constraints in the Poisson or in the Hawkes framework are highlighted. Moreover, they share adaptive properties that are useful from a practical point of view. We show the performance of those methods on simulated data. We also provide a complete analysis with these tools on single unit activity recorded on a monkey during a sensory-motor task.Electronic Supplementary MaterialThe online version of this article (doi:10.1186/2190-8567-4-3) contains supplementary material.

| S-EPMC4021619 | biostudies-literature

Goodness of Fit Tests for Linear Mixed Models.

Project description:Linear mixed models (LMMs) are widely used for regression analysis of data that are assumed to be clustered or correlated. Assessing model fit is important for valid inference but to date no confirmatory tests are available to assess the adequacy of the fixed effects part of LMMs against general alternatives. We therefore propose a class of goodness-of-fit tests for the mean structure of LMMs. Our test statistic is a quadratic form of the difference between observed values and the values expected under the estimated model in cells defined by a partition of the covariate space. We show that this test statistic has an asymptotic chi-squared distribution when model parameters are estimated by maximum likelihood or by least squares and method of moments, and study its power under local alternatives both analytically and in simulations. Data on repeated measurements of thyroglobulin from individuals exposed to the accident at the Chernobyl power plant in 1986 are used to illustrate the proposed test.

| S-EPMC5426279 | biostudies-literature

Goodness of fit tests for random multigraph models.

Project description:Goodness of fit tests for two probabilistic multigraph models are presented. The first model is random stub matching given fixed degrees (RSM) so that edge assignments to vertex pair sites are dependent, and the second is independent edge assignments (IEA) according to a common probability distribution. Tests are performed using goodness of fit measures between the edge multiplicity sequence of an observed multigraph, and the expected one according to a simple or composite hypothesis. Test statistics of Pearson type and of likelihood ratio type are used, and the expected values of the Pearson statistic under the different models are derived. Test performances based on simulations indicate that even for small number of edges, the null distributions of both statistics are well approximated by their asymptotic χ2-distribution. The non-null distributions of the test statistics can be well approximated by proposed adjusted χ2-distributions used for power approximations. The influence of RSM on both test statistics is substantial for small number of edges and implies a shift of their distributions towards smaller values compared to what holds true for the null distributions under IEA. Two applications on social networks are included to illustrate how the tests can guide in the analysis of social structure.

| S-EPMC10631392 | biostudies-literature

Nonparametric goodness-of-fit testing for parametric covariate models in pharmacometric analyses.

Project description:The characterization of covariate effects on model parameters is a crucial step during pharmacokinetic/pharmacodynamic analyses. Although covariate selection criteria have been studied extensively, the choice of the functional relationship between covariates and parameters, however, has received much less attention. Often, a simple particular class of covariate-to-parameter relationships (linear, exponential, etc.) is chosen ad hoc or based on domain knowledge, and a statistical evaluation is limited to the comparison of a small number of such classes. Goodness-of-fit testing against a nonparametric alternative provides a more rigorous approach to covariate model evaluation, but no such test has been proposed so far. In this manuscript, we derive and evaluate nonparametric goodness-of-fit tests for parametric covariate models, the null hypothesis, against a kernelized Tikhonov regularized alternative, transferring concepts from statistical learning to the pharmacological setting. The approach is evaluated in a simulation study on the estimation of the age-dependent maturation effect on the clearance of a monoclonal antibody. Scenarios of varying data sparsity and residual error are considered. The goodness-of-fit test correctly identified misspecified parametric models with high power for relevant scenarios. The case study provides proof-of-concept of the feasibility of the proposed approach, which is envisioned to be beneficial for applications that lack well-founded covariate models.

| S-EPMC8213422 | biostudies-literature

Empirical likelihood-based tests for stochastic ordering.

Project description:This paper develops an empirical likelihood approach to testing for the presence of stochastic ordering among univariate distributions based on independent random samples from each distribution. The proposed test statistic is formed by integrating a localized empirical likelihood statistic with respect to the empirical distribution of the pooled sample. The asymptotic null distribution of this test statistic is found to have a simple distribution-free representation in terms of standard Brownian bridge processes. The approach is used to compare the lengths of rule of Roman Emperors over various historical periods, including the "decline and fall" phase of the empire. In a simulation study, the power of the proposed test is found to improve substantially upon that of a competing test due to El Barmi and Mukerjee.

| S-EPMC3716296 | biostudies-literature

An Evaluation of Overall Goodness-of-Fit Tests for the Rasch Model.

Project description:For assessing the fit of item response theory models, it has been suggested to apply overall goodness-of-fit tests as well as tests for individual items and item pairs. Although numerous goodness-of-fit tests have been proposed in the literature for the Rasch model, their relative power against several model violations has not been investigated so far. This study compares four of these tests, which are all available in R software: T 10, T 11, M 2, and the LR test. Results on the Type I error rate and the sensitivity to violations of different assumptions of the Rasch model (unidimensionality, local independence on the level of item pairs, equal item discrimination, zero as a lower asymptote for the item characteristic curves, invariance of the item parameters) are reported. The results indicate that the T 11 test is comparatively most powerful against violations of the assumption of parallel item characteristic curves, which includes the presence of unequal item discriminations and a non-zero lower asymptote. Against the remaining model violations, which can be summarized as local dependence, M 2 is found to be most powerful. T 10 and LR are found to be sensitive against violations of the assumption of parallel item characteristic curves, but are insensitive against local dependence.

| S-EPMC6335387 | biostudies-literature

Goodness-of-fit tests and model diagnostics for negative binomial regression of RNA sequencing data.

Project description:This work is about assessing model adequacy for negative binomial (NB) regression, particularly (1) assessing the adequacy of the NB assumption, and (2) assessing the appropriateness of models for NB dispersion parameters. Tools for the first are appropriate for NB regression generally; those for the second are primarily intended for RNA sequencing (RNA-Seq) data analysis. The typically small number of biological samples and large number of genes in RNA-Seq analysis motivate us to address the trade-offs between robustness and statistical power using NB regression models. One widely-used power-saving strategy, for example, is to assume some commonalities of NB dispersion parameters across genes via simple models relating them to mean expression rates, and many such models have been proposed. As RNA-Seq analysis is becoming ever more popular, it is appropriate to make more thorough investigations into power and robustness of the resulting methods, and into practical tools for model assessment. In this article, we propose simulation-based statistical tests and diagnostic graphics to address model adequacy. We provide simulated and real data examples to illustrate that our proposed methods are effective for detecting the misspecification of the NB mean-variance relationship as well as judging the adequacy of fit of several NB dispersion models.

| S-EPMC4365073 | biostudies-literature

Goodness-of-fit test for meta-analysis.

Project description:Meta-analysis is a very useful tool to combine information from different sources. Fixed effect and random effect models are widely used in meta-analysis. Despite their popularity, they may give us misleading results if the models don't fit the data but are blindly used. Therefore, like any statistical analysis, checking the model fitting is an important step. However, in practice, the goodness-of-fit in meta-analysis is rarely discussed. In this paper, we propose some tests to check the goodness-of-fit for the fixed and random effect models with assumption of normal distributions in meta-analysis. Through simulation study, we show that the proposed tests control type I error rate very well. To demonstrate the usefulness of the proposed tests, we also apply them to some real data sets. Our study shows that the proposed tests are useful tools in checking the goodness-of-fit of the normal models used in meta-analysis.

| S-EPMC4655309 | biostudies-other

Goodness-of-fit diagnostics for Bayesian hierarchical models.

Project description:This article proposes methodology for assessing goodness of fit in Bayesian hierarchical models. The methodology is based on comparing values of pivotal discrepancy measures (PDMs), computed using parameter values drawn from the posterior distribution, to known reference distributions. Because the resulting diagnostics can be calculated from standard output of Markov chain Monte Carlo algorithms, their computational costs are minimal. Several simulation studies are provided, each of which suggests that diagnostics based on PDMs have higher statistical power than comparable posterior-predictive diagnostic checks in detecting model departures. The proposed methodology is illustrated in a clinical application; an application to discrete data is described in supplementary material.

| S-EPMC3276744 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data