Ontology highlight
ABSTRACT:
SUBMITTER: Hwang I
PROVIDER: S-EPMC5771393 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Hwang Inah I Oh Hwanhee H Santo Evan E Kim Do-Yeon DY Chen John W JW Bronson Roderick T RT Locasale Jason W JW Na Yoonmi Y Lee Jaclyn J Reed Stewart S Toth Miklos M Yu Wai H WH Muller Florian L FL Paik Jihye J
Aging cell 20171126 1
Neurodegeneration resulting in cognitive and motor impairment is an inevitable consequence of aging. Little is known about the genetic regulation of this process despite its overriding importance in normal aging. Here, we identify the Forkhead Box O (FOXO) transcription factor 1, 3, and 4 isoforms as a guardian of neuronal integrity by inhibiting age-progressive axonal degeneration in mammals. FOXO expression progressively increased in aging human and mouse brains. The nervous system-specific de ...[more]