Ontology highlight
ABSTRACT:
SUBMITTER: Vijayakumar A
PROVIDER: S-EPMC5771491 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Vijayakumar Archana A Aryal Pratik P Wen Jennifer J Syed Ismail I Vazirani Reema P RP Moraes-Vieira Pedro M PM Camporez Joao Paulo JP Gallop Molly R MR Perry Rachel J RJ Peroni Odile D OD Shulman Gerald I GI Saghatelian Alan A McGraw Timothy E TE Kahn Barbara B BB
Cell reports 20171001 4
Lower adipose-ChREBP and de novo lipogenesis (DNL) are associated with insulin resistance in humans. Here, we generated adipose-specific ChREBP knockout (AdChREBP KO) mice with negligible sucrose-induced DNL in adipose tissue (AT). Chow-fed AdChREBP KO mice are insulin resistant with impaired insulin action in the liver, muscle, and AT and increased AT inflammation. HFD-fed AdChREBP KO mice are also more insulin resistant than controls. Surprisingly, adipocytes lacking ChREBP display a cell-auto ...[more]