Ontology highlight
ABSTRACT:
SUBMITTER: Ha ID
PROVIDER: S-EPMC5771528 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ha Il Do ID Christian Nicholas J NJ Jeong Jong-Hyeon JH Park Junwoo J Lee Youngjo Y
Statistical methods in medical research 20140311 6
Competing risks data often exist within a center in multi-center randomized clinical trials where the treatment effects or baseline risks may vary among centers. In this paper, we propose a subdistribution hazard regression model with multivariate frailty to investigate heterogeneity in treatment effects among centers from multi-center clinical trials. For inference, we develop a hierarchical likelihood (or h-likelihood) method, which obviates the need for an intractable integration over the fra ...[more]