The Spleen Is an HIV-1 Sanctuary During Combined Antiretroviral Therapy.
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ABSTRACT:
SUBMITTER: Nolan DJ
PROVIDER: S-EPMC5771542 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
The Spleen Is an HIV-1 Sanctuary During Combined Antiretroviral Therapy.
Nolan David J DJ Rose Rebecca R Rodriguez Patricia H PH Salemi Marco M Singer Elyse J EJ Lamers Susanna L SL McGrath Michael S MS
AIDS research and human retroviruses 20171130 1
Combined antiretroviral therapy (cART) does not eradicate HIV, which persists for years and can re-establish replication if treatment is stopped. The current challenge is identifying those tissues harboring virus through cART. Here, we used HIV env-nef single genome sequencing and HIV gag droplet digital PCR (ddPCR) to survey 50 tissues from five subjects on cART with no detectable plasma viral load at death. The spleen most consistently contained multiple proviral and expressed sequences (4/5 p ...[more]
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