Ontology highlight
ABSTRACT:
SUBMITTER: Wu M
PROVIDER: S-EPMC5771864 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wu Mengyun M Huang Jian J Ma Shuangge S
Statistics in medicine 20171016 4
Gene-gene (G×G) interactions have been shown to be critical for the fundamental mechanisms and development of complex diseases beyond main genetic effects. The commonly adopted marginal analysis is limited by considering only a small number of G factors at a time. With the "main effects, interactions" hierarchical constraint, many of the existing joint analysis methods suffer from prohibitively high computational cost. In this study, we propose a new method for identifying important G×G interact ...[more]