Ontology highlight
ABSTRACT:
SUBMITTER: Howson LJ
PROVIDER: S-EPMC5772558 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Howson Lauren J LJ Napolitani Giorgio G Shepherd Dawn D Ghadbane Hemza H Kurupati Prathiba P Preciado-Llanes Lorena L Rei Margarida M Dobinson Hazel C HC Gibani Malick M MM Teng Karen Wei Weng KWW Newell Evan W EW Veerapen Natacha N Besra Gurdyal S GS Pollard Andrew J AJ Cerundolo Vincenzo V
Nature communications 20180117 1
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-derived metabolites presented on MR1. Here we show, using a controlled infection of humans with live Salmonella enterica serovar Paratyphi A, that MAIT cells are activated during infection, an effect maintained even after antibiotic treatment. At the peak of infection MAIT cell T-cell receptor (TCR)β clonotypes that are over-represented prior to infection transiently contract. Select MAIT cell TCRβ clono ...[more]