Ontology highlight
ABSTRACT:
SUBMITTER: Frith JE
PROVIDER: S-EPMC5772625 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Frith Jessica E JE Kusuma Gina D GD Carthew James J Li Fanyi F Cloonan Nicole N Gomez Guillermo A GA Cooper-White Justin J JJ
Nature communications 20180117 1
Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation, migration and differentiation. However, when incorporating MSCs within injectable, inherently soft hydrogels, this dominance over MSC response substantially limits our ability to couple the ease of application of hydrogels with efficiently directed MSC differentiation, especially in the case of bone generation. Here, we identify differential mi ...[more]