Prebiotic formation of cyclic dipeptides under potentially early Earth conditions.

ABSTRACT: Cyclic dipeptides, also known as 2,5-diketopiperazines (DKPs), represent the simplest peptides that were first completely characterized. DKPs can catalyze the chiral selection of reactions and are considered as peptide precursors. The origin of biochemical chirality and synthesis of peptides remains abstruse problem believed to be essential precondition to origin of life. Therefore, it is reasonable to believe that the DKPs could have played a key role in the origin of life. How the formation of the DKPs through the condensation of unprotected amino acids in simulated prebiotic conditions has been unclear. Herein, it was found that cyclo-Pro-Pro could be formed directly from unprotected proline in the aqueous solution of trimetaphosphate (P₃m) under mild condition with the yield

SUBMITTER: Ying J 

PROVIDER: S-EPMC5772641 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature