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Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes.


ABSTRACT: Evening chronotype associates with health complications possibly via lifestyle factors, while the contribution of genetics is unknown. The aim was to study the relative contributions of genetics, lifestyle, and circadian-related physiological characteristics in metabolic risk of evening chronotype. In order to capture a biological contribution to chronotype, a genetic-risk-score (GRS), comprised of 15 chronotype-related variants, was tested. Moreover, a wide range of behavioral and emotional eating factors was studied within the same population. Chronotype, lifestyle, and metabolic syndrome (MetS) outcomes were assessed (n?=?2,126), in addition to genetics (n?=?1,693) and rest-activity/wrist-temperature rhythms (n?=?100). Evening chronotype associated with MetS and insulin resistance (P?

SUBMITTER: Vera B 

PROVIDER: S-EPMC5772646 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes.

Vera Beatriz B   Dashti Hassan S HS   Gómez-Abellán Purificación P   Hernández-Martínez Antonio M AM   Esteban Alberto A   Scheer Frank A J L FAJL   Saxena Richa R   Garaulet Marta M  

Scientific reports 20180117 1


Evening chronotype associates with health complications possibly via lifestyle factors, while the contribution of genetics is unknown. The aim was to study the relative contributions of genetics, lifestyle, and circadian-related physiological characteristics in metabolic risk of evening chronotype. In order to capture a biological contribution to chronotype, a genetic-risk-score (GRS), comprised of 15 chronotype-related variants, was tested. Moreover, a wide range of behavioral and emotional eat  ...[more]

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