Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
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ABSTRACT:
SUBMITTER: Jiang X
PROVIDER: S-EPMC5772647 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Jiang Xia X O'Reilly Paul F PF Aschard Hugues H Aschard Hugues H Hsu Yi-Hsiang YH Richards J Brent JB Dupuis Josée J Ingelsson Erik E Karasik David D Pilz Stefan S Berry Diane D Kestenbaum Bryan B Zheng Jusheng J Luan Jianan J Sofianopoulou Eleni E Streeten Elizabeth A EA Albanes Demetrius D Lutsey Pamela L PL Yao Lu L Tang Weihong W Econs Michael J MJ Wallaschofski Henri H Völzke Henry H Zhou Ang A Power Chris C McCarthy Mark I MI Michos Erin D ED Boerwinkle Eric E Weinstein Stephanie J SJ Freedman Neal D ND Huang Wen-Yi WY Van Schoor Natasja M NM van der Velde Nathalie N Groot Lisette C P G M de LCPGM Enneman Anke A Cupples L Adrienne LA Booth Sarah L SL Vasan Ramachandran S RS Liu Ching-Ti CT Zhou Yanhua Y Ripatti Samuli S Ohlsson Claes C Vandenput Liesbeth L Lorentzon Mattias M Eriksson Johan G JG Shea M Kyla MK Houston Denise K DK Kritchevsky Stephen B SB Liu Yongmei Y Lohman Kurt K KK Ferrucci Luigi L Peacock Munro M Gieger Christian C Beekman Marian M Slagboom Eline E Deelen Joris J Heemst Diana van DV Kleber Marcus E ME März Winfried W de Boer Ian H IH Wood Alexis C AC Rotter Jerome I JI Rich Stephen S SS Robinson-Cohen Cassianne C den Heijer Martin M Jarvelin Marjo-Riitta MR Cavadino Alana A Joshi Peter K PK Wilson James F JF Hayward Caroline C Lind Lars L Michaëlsson Karl K Trompet Stella S Zillikens M Carola MC Uitterlinden Andre G AG Rivadeneira Fernando F Broer Linda L Zgaga Lina L Campbell Harry H Theodoratou Evropi E Farrington Susan M SM Timofeeva Maria M Dunlop Malcolm G MG Valdes Ana M AM Tikkanen Emmi E Lehtimäki Terho T Lyytikäinen Leo-Pekka LP Kähönen Mika M Raitakari Olli T OT Mikkilä Vera V Ikram M Arfan MA Sattar Naveed N Jukema J Wouter JW Wareham Nicholas J NJ Langenberg Claudia C Forouhi Nita G NG Gundersen Thomas E TE Khaw Kay-Tee KT Butterworth Adam S AS Danesh John J Spector Timothy T Wang Thomas J TJ Hyppönen Elina E Kraft Peter P Kiel Douglas P DP
Nature communications 20180117 1
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10<sup>-9</sup> at rs801 ...[more]
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