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Synthesis of Chondroitin Sulfate A Bearing Syndecan-1 Glycopeptide.

ABSTRACT: Syndecan-1 chondroitin sulfate glycopeptide was synthesized for the first time using the cassette approach. The sequence of glycosylation to form the octasaccharide serine cassette was critical. The glycopeptide was successfully assembled via a 2+ (3 + 3) glycosylation strategy followed by peptide chain elongation.

SUBMITTER: Ramadan S

PROVIDER: S-EPMC5772981 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Synthesis of Chondroitin Sulfate A Bearing Syndecan-1 Glycopeptide.

Ramadan Sherif S Yang Weizhun W Zhang Zeren Z Huang Xuefei X

Organic letters 20170829 18

Syndecan-1 chondroitin sulfate glycopeptide was synthesized for the first time using the cassette approach. The sequence of glycosylation to form the octasaccharide serine cassette was critical. The glycopeptide was successfully assembled via a 2+ (3 + 3) glycosylation strategy followed by peptide chain elongation. ...[more]

PMID: 28849661

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