Ontology highlight
ABSTRACT:
SUBMITTER: Suhardi VJ
PROVIDER: S-EPMC5773111 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Suhardi V J VJ Bichara D A DA Kwok Sjj S Freiberg A A AA Rubash H H Malchau H H Yun S H SH Muratoglu O K OK Oral E E
Nature biomedical engineering 20170613
Despite advances in orthopedic materials, the development of drug-eluting bone and joint implants that can sustain the delivery of the drug and maintain the necessary mechanical strength in order to withstand loading has remained elusive. Here, we demonstrate that modifying the eccentricity of drug clusters and the percolation threshold in ultrahigh molecular weight polyethylene (UHMWPE) results in maximized drug elution and in the retention of mechanical strength. The optimized UHMWPE eluted an ...[more]