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Aspirin and incident depressive symptoms: A longitudinal cohort study over 8 years.


ABSTRACT: OBJECTIVE:Aspirin exhibits anti-atherosclerotic and anti-inflammatory properties-two potential risk factors for depression. The relationship between aspirin use and depression, however, remains unclear. We investigated whether the aspirin use is associated with a decreased incidence of depressive symptoms in a large North American cohort. METHODS:Data from the Osteoarthritis Initiative dataset, a multicenter, longitudinal study on community-dwelling adults was analyzed. Aspirin use was defined through self-report in the past 30 days and confirmed by a trained interviewer. Incident depressive symptoms were defined as a score of ?16 in the 20-item Center for Epidemiologic Studies-Depression scale. RESULTS:A total of 137 participants (mean age 65 y, 55.5% female) were using aspirin at baseline. Compared with 4003 participants not taking aspirin, no differences in Center for Epidemiologic Studies-Depression at baseline were evident (P = .65). After a median follow-up time of 8 years, the incidence of depressive symptoms was similar in those taking aspirin at baseline (43; 95% CI, 3-60) and in aspirin nonusers (38; 95% CI, 36-41) per 1000 y; log-rank test = 0.63). Based on Cox's regression analysis adjusted for 11 potential confounders, aspirin use was not significantly associated with the development of depressive symptoms (hazard ratio = 1.12; 95% CI, 0.78-1.62; P = .54). Adjustment for propensity scores or the use of propensity score matching did not alter the results. CONCLUSION:Our study found that prescription of aspirin offered no significant protection against incident depressive symptoms. Whether aspirin is beneficial in a subgroup of depression with high levels of inflammation remains to be investigated in future studies.

SUBMITTER: Veronese N 

PROVIDER: S-EPMC5773347 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Aspirin and incident depressive symptoms: A longitudinal cohort study over 8 years.

Veronese Nicola N   Koyanagi Ai A   Stubbs Brendon B   Solmi Marco M   Fornaro Michele M   Fernandes Brisa S BS   Mueller Christoph C   Thompson Trevor T   Carvalho André F AF   Maggi Stefania S  

International journal of geriatric psychiatry 20170806 2


<h4>Objective</h4>Aspirin exhibits anti-atherosclerotic and anti-inflammatory properties-two potential risk factors for depression. The relationship between aspirin use and depression, however, remains unclear. We investigated whether the aspirin use is associated with a decreased incidence of depressive symptoms in a large North American cohort.<h4>Methods</h4>Data from the Osteoarthritis Initiative dataset, a multicenter, longitudinal study on community-dwelling adults was analyzed. Aspirin us  ...[more]

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