Ontology highlight
ABSTRACT:
SUBMITTER: Bloch Y
PROVIDER: S-EPMC5773378 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Bloch Yehudi Y Bouchareychas Laura L Merceron Romain R Składanowska Katarzyna K Van den Bossche Lien L Detry Sammy S Govindarajan Srinath S Elewaut Dirk D Haerynck Filomeen F Dullaers Melissa M Adamopoulos Iannis E IE Savvides Savvas N SN
Immunity 20171226 1
Interleukin-23 (IL-23), an IL-12 family cytokine, plays pivotal roles in pro-inflammatory T helper 17 cell responses linked to autoimmune and inflammatory diseases. Despite intense therapeutic targeting, structural and mechanistic insights into receptor complexes mediated by IL-23, and by IL-12 family members in general, have remained elusive. We determined a crystal structure of human IL-23 in complex with its cognate receptor, IL-23R, and revealed that IL-23R bound to IL-23 exclusively via its ...[more]