Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5773387 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yang Hongbin H de Jong Johannes W JW Tak YeEun Y Peck James J Bateup Helen S HS Lammel Stephan S
Neuron 20180104 2
Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assays, we identify principles of afferent-specific control in the mesolimbic DA system. Neurons in the medial shell subdivision of the nucleus accumbens (NAc) exert direct inhibitory co ...[more]