Ontology highlight
ABSTRACT:
SUBMITTER: van Wietmarschen N
PROVIDER: S-EPMC5773480 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
van Wietmarschen Niek N Merzouk Sarra S Halsema Nancy N Spierings Diana C J DCJ Guryev Victor V Lansdorp Peter M PM
Nature communications 20180118 1
Bloom syndrome is a cancer predisposition disorder caused by mutations in the BLM helicase gene. Cells from persons with Bloom syndrome exhibit striking genomic instability characterized by excessive sister chromatid exchange events (SCEs). We applied single-cell DNA template strand sequencing (Strand-seq) to map the genomic locations of SCEs. Our results show that in the absence of BLM, SCEs in human and murine cells do not occur randomly throughout the genome but are strikingly enriched at cod ...[more]