CA1 and CA3 differentially support spontaneous retrieval of episodic contexts within human hippocampal subfields.

ABSTRACT: The hippocampus plays a critical role in spatial and episodic memory. Mechanistic models predict that hippocampal subfields have computational specializations that differentially support memory. However, there is little empirical evidence suggesting differences between the subfields, particularly in humans. To clarify how hippocampal subfields support human spatial and episodic memory, we developed a virtual reality paradigm where participants passively navigated through houses (spatial contexts) across a series of videos (episodic contexts). We then used multivariate analyses of high-resolution fMRI data to identify neural representations of contextual information during recollection. Multi-voxel pattern similarity analyses revealed that CA1 represented objects that shared an episodic con

SUBMITTER: Dimsdale-Zucker HR 

PROVIDER: S-EPMC5773497 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature